Details

Autor(en) / Beteiligte

• Mei, H
• Rice, T K
• Gu, D
• Hixson, J E
• Jaquish, C E
• Zhao, Qi
• Chen, J-C
• Cao, J
• Li, J
• Kelly, T N
• Rao, D C
• He, J

Titel

Genetic correlation of blood pressure responses to dietary sodium and potassium intervention and cold pressor test in chinese population

Ist Teil von

• Journal of human hypertension, 2011-08, Vol.25 (8), p.500-508

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• We examined the genetic association between blood pressure (BP) responses to dietary sodium and potassium intervention and to cold pressor test (CPT) in a large family-based dietary feeding study. The dietary intervention and CPT were conducted among 1906 participants in rural China. The dietary intervention included three 7-day periods of low-sodium feeding (51.3 mmol per day), high-sodium feeding (307.8 mmol per day) and high-sodium feeding plus potassium supplementation (60 mmol per day). BP responses to high-sodium intervention had strong genetic correlations ( ρ G ) with both BP responses to low sodium ( ρ G =−0.43 to −0.54, P -values=0.0005 to 0.03) and to potassium supplementation ( ρ G =−0.41 to −0.49, P -values=0.001 to 0.005) interventions. Most environmental correlations between BP responses to various dietary interventions were significant. The ρ G between BP responses to CPT and to high-sodium intervention and potassium supplementation were statistically significant. For example, the ρ G between maximum BP responses to CPT and BP responses to high-sodium intervention was 0.37 ( P =0.006) for systolic BP (SBP) and 0.41 ( P =0.002) for diastolic BP (DBP). The ρ G between maximum BP responses to CPT and BP responses to potassium intervention was −0.42 ( P =0.001) for SBP and −0.46 ( P =0.001) for SBP. Our study suggests that there are common genetic determinants that influence BP responses to dietary sodium and potassium interventions and to CPT.