Psychiatry research. Neuroimaging, 2011-09, Vol.193 (3), p.151-160
2011
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- The attenuation of dysfunctional emotional processing with stimulant medication: An fMRI study of adolescents with ADHD
- Ist Teil von
- Psychiatry research. Neuroimaging, 2011-09, Vol.193 (3), p.151-160
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2011
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Abstract Functional neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the neural correlates of cognitive control. However, for many youths with ADHD, emotional lability is an important clinical feature of the disorder. We aimed to identify the neural substrates associated with emotional lability that were distinct from impairments in cognitive control and to assess the effects that stimulants have on those substrates. We used functional magnetic resonance imaging (fMRI) to assess neural activity in adolescents with ( N = 15) and without ( N = 15) ADHD while they performed cognitive and emotional versions of the Stroop task that engage cognitive control and emotional processing, respectively. The participants with ADHD were scanned both on and off stimulant medication in a counterbalanced fashion. Controlling for differences in cognitive control, we found that during the emotional Stroop task, adolescents with ADHD as compared with controls demonstrated atypical activity in the medial prefrontal cortex (mPFC). Stimulants attenuated activity in the mPFC to levels comparable with controls.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0925-4927eISSN: 1872-7506DOI: 10.1016/j.pscychresns.2011.02.005Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3164556
- Format
- –
- Schlagworte
- Adolescent, Affective Symptoms - drug therapy, Affective Symptoms - etiology, Attention Deficit Disorder with Hyperactivity - complications, Attention Deficit Disorder with Hyperactivity - pathology, Biological and medical sciences, Brain Mapping, Case-Control Studies, Central Nervous System Stimulants - pharmacology, Central Nervous System Stimulants - therapeutic use, Chi-Square Distribution, Cognition Disorders - etiology, Cognitive control, Emotional lability, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Medial prefrontal cortex, Medical sciences, Neuropharmacology, Neuropsychological Tests, Oxygen - blood, Pharmacology. Drug treatments, Photic Stimulation, Prefrontal Cortex - blood supply, Prefrontal Cortex - drug effects, Prefrontal Cortex - pathology, Psychiatric Status Rating Scales, Psychiatry, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Radiology, Reaction Time - drug effects, Statistics as Topic, Statistics, Nonparametric, Stroop