Details

Autor(en) / Beteiligte

• Brawn, Ryan A
• Welzel, Morgan
• Lowe, Jason T
• Panek, James S

Titel

Regioselective Intramolecular Dipolar Cycloaddition of Azides and Unsymmetrical Alkynes

Ist Teil von

• Organic letters, 2010-01, Vol.12 (2), p.336-339

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Enantioenriched allenylsilanes are used in three-component propargylation reactions with aldehydes and silyl ethers to form syn-homopropargylic ethers that contain an imbedded azide. These materials then undergo thermally induced intramolecular 1,3-dipolar cycloaddition reactions, resulting in unique fused ring systems containing 1,2,3-triazoles. The ability to modify all three components of the reaction allows for expedient access to compounds containing significant structural and stereochemical variation.