Details

Autor(en) / Beteiligte

• Arnaoutakis, George J.
• Rangachari, Deepa
• Laheru, Daniel A.
• Iacobuzio-Donahue, Chris A.
• Hruban, Ralph H.
• Herman, Joseph M.
• Edil, Barish H.
• Pawlik, Timothy M.
• Schulick, Richard D.
• Cameron, John L.
• Meneshian, Avedis
• Yang, Stephen C.
• Wolfgang, Christopher L.

Titel

Pulmonary Resection for Isolated Pancreatic Adenocarcinoma Metastasis: an Analysis of Outcomes and Survival

Ist Teil von

• Journal of gastrointestinal surgery, 2011-09, Vol.15 (9), p.1611-1617

Ort / Verlag

New York: Springer-Verlag

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives This study was conducted to determine if pulmonary metastasectomy (PM) for isolated pancreatic cancer metastases is safe and effective. Methods This was a retrospective case–control study of patients undergoing PM at our institution from 2000 to 2009 for isolated lung metastasis after resection for pancreatic cancer. Clinical and pathologic data were compared with a matched reference group. Resected neoplasms were immunolabeled for the Dpc4 protein. Kaplan–Meier analysis compared overall survival and survival after relapse. Results Of 31 patients with isolated lung metastasis, 9 underwent 10 pulmonary resections. At initial pancreas resection, all patients were stage I or II. Other baseline characteristics were similar between the two groups. Median time from pancreatectomy to PM was 34 months (interquartile range 21–49). During the study, 29/31(90.6%) patients died. There were no in-hospital mortalities or complications after PM. Median cumulative survival was significantly improved in the PM group (51 vs. 23 months, p  = 0.04). There was a trend toward greater 2-year survival after relapse in the PM group (40% vs. 27%, p  = 0.2). Conclusions In patients with isolated lung metastasis from pancreatic adenocarcinoma, this is the first study to show that pulmonary resection can be performed safely with low morbidity and mortality. The improved survival in the PM group may result in part from selection bias but may also represent a benefit of the procedure.