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Details

Autor(en) / Beteiligte
Titel
13C MRS of occipital and frontal lobes at 3 T using a volume coil for stochastic proton decoupling
Ist Teil von
  • NMR in biomedicine, 2010-10, Vol.23 (8), p.977-985
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • Previously, we devised a novel strategy for in vivo 13C MRS using [2‐13C]glucose infusion and low‐power proton decoupling, and proposed that this strategy could be used to acquire 13C MR spectra from the frontal lobe of the human brain. Here, we demonstrate, for the first time, in vivo 13C MRS of human frontal lobe acquired at 3 T. Because the primary metabolites of [2‐13C]glucose can be decoupled using very‐low‐radiofrequency power, we used a volume coil for proton decoupling in this study. The homogeneous B1 field of the volume coil was found to significantly enhance the decoupling efficiency of the stochastic decoupling sequence. Detailed specific absorption rates inside the human head were analyzed using the finite difference time domain method to ensure experimental safety. In vivo 13C spectra from the occipital and frontal lobes of the human brain were obtained. At a decoupling power of 30 W (time‐averaged power, 2.45 W), the spectra from the occipital lobe showed well‐resolved spectral resolution and excellent signal‐to‐noise ratio. Although frontal lobe 13C spectra were affected by local B0 field inhomogeneity, we demonstrated that the spectral quality could be improved using post‐acquisition data processing. In particular, we showed that the frontal lobe glutamine C5 at 178.5 ppm and aspartate C4 at 178.3 ppm could be spectrally resolved with effective proton decoupling and B0 field correction. Because of its large spatial coverage, volume coil decoupling provides the potential to acquire 13C MRS from more than one brain region simultaneously. Copyright © 2010 John Wiley & Sons, Ltd. We demonstrate that [2‐13C]glucose metabolism can be studied in both the occipital and frontal lobes of human brain at 3 T using a volume coil for stochastic proton decoupling. The pattern of glucose metabolism in the frontal lobe was found to be highly similar to that in the occipital lobe with 13C labels from [2‐13C]glucose incorporated into glutamate, glutamine, aspartate and N‐acetylaspartate carboxylic/amide carbons. In particular, the frontal lobe signal at 178.4 ppm was contributed by both glutamine C5 and aspartate C4.

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