Details

Autor(en) / Beteiligte

• Boca, Simina M
• Kinzler, Kenneth W
• Velculescu, Victor E
• Vogelstein, Bert
• Parmigiani, Giovanni

Titel

Patient-oriented gene set analysis for cancer mutation data

Ist Teil von

• Genome biology, 2010-01, Vol.11 (11), p.R112-R112

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2010

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Recent research has revealed complex heterogeneous genomic landscapes in human cancers. However, mutations tend to occur within a core group of pathways and biological processes that can be grouped into gene sets. To better understand the significance of these pathways, we have developed an approach that initially scores each gene set at the patient rather than the gene level. In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods.