Details

Autor(en) / Beteiligte

• Sharif, Roozbeh, MD
• Mayes, Maureen D., MD, MPH
• Nicassio, Perry M., PhD
• Gonzalez, Emilio B., MD
• Draeger, Hilda, MD
• McNearney, Terry A., MD
• Estrada-Y-Martin, Rosa M., MD, MSc, FCCP
• Nair, Deepthi K., MS
• Reveille, John D., MD
• Arnett, Frank C., MD
• Assassi, Shervin, MD, MS

Titel

Determinants of Work Disability in Patients with Systemic Sclerosis: A Longitudinal Study of the GENISOS Cohort

Ist Teil von

• Seminars in arthritis and rheumatism, 2011-08, Vol.41 (1), p.38-47

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives To determine the prevalence, correlates, and predictors of work disability (WD) in the G enetics versus EN vironment I n S cleroderma O utcome S tudy (GENISOS). We hypothesized that WD in systemic sclerosis (SSc) is a function of demographic, clinical, and psychosocial factors. Methods Patients enrolled in the GENISOS cohort were subdivided in 3 groups: work disabled, working, and retired or homemakers. The latter group ( n = 29) was excluded from further analysis. We used logistic regression analysis with a forward hierarchical variable selection strategy to investigate the independent correlates of WD at enrollment. Cox regression proportional Hazard's model with a similar variable selection strategy was utilized to determine the predictors of WD in those working at enrollment. Results Overall, 284 patients with a mean age of 48.7 years and disease duration of 2.5 (±1.6) years were enrolled into the GENISOS cohort, consisting of 83.5% female, 46.8% white, 28.9% Hispanic, and 20.4% African American. Patients were longitudinally followed in 1438 study visits. At enrollment, 124 patients (43.7%) were work disabled, whereas 131 (46.1%) were working. Lower level of education ( P < 0.001), higher Medsger Lung Severity Index ( P = 0.012), higher Fatigue Severity Score ( P = 0.008), and less social support ( P < 0.001) correlated independently with WD. Of those working at baseline, 35 (26.7%) eventually developed WD. Non-white ethnicity ( P = 0.038), lower DLCO % predicted value ( P = 0.038), and higher Fatigue Severity Score ( P = 0.009) at enrollment independently predicted WD on follow-up visits. Conclusions WD is a major problem among SSc patients and its prevalence is substantially higher than other rheumatic conditions. Demographic, clinical, and psychosocial factors correlate with WD cross-sectionally and predict WD longitudinally in these patients.