Details

Autor(en) / Beteiligte

• Baas, Peter W.
• Lin, Shen

Titel

Hooks and comets: The story of microtubule polarity orientation in the neuron

Ist Teil von

• Developmental neurobiology (Hoboken, N.J.), 2011-06, Vol.71 (6), p.403-418

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2011

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• It is widely believed that signature patterns of microtubule polarity orientation within axons and dendrites underlie compositional and morphological differences that distinguish these neuronal processes from one another. Axons of vertebrate neurons display uniformly plus‐end‐distal microtubules, whereas their dendrites display non‐uniformly oriented microtubules. Recent studies on insect neurons suggest that it is the minus‐end‐distal microtubules that are the critical feature of the dendritic microtubule array, whether or not they are accompanied by plus‐end‐distal microtubules. Discussed in this article are the history of these findings, their implications for the regulation of neuronal polarity across the animal kingdom, and potential mechanisms by which neurons establish the distinct microtubule polarity patterns that define axons and dendrites. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 403–418, 2011