UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 9 von 39628
Datensatz exportieren als...
BibTeX
Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures
Journal of bone and mineral research, 2010-12, Vol.25 (12), p.2572-2581
Stein, Emily M
Liu, X Sherry
Nickolas, Thomas L
Cohen, Adi
Thomas, Valerie
McMahon, Donald J
Zhang, Chiyuan
Yin, Perry T
Cosman, Felicia
Nieves, Jeri
Guo, X Edward
Shane, Elizabeth
2010
Details
Autor(en) / Beteiligte
Stein, Emily M
Liu, X Sherry
Nickolas, Thomas L
Cohen, Adi
Thomas, Valerie
McMahon, Donald J
Zhang, Chiyuan
Yin, Perry T
Cosman, Felicia
Nieves, Jeri
Guo, X Edward
Shane, Elizabeth
Titel
Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures
Ist Teil von
Journal of bone and mineral research, 2010-12, Vol.25 (12), p.2572-2581
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Measurement of areal bone mineral density (aBMD) by dual‐energy x‐ray absorptiometry (DXA) has been shown to predict fracture risk. High‐resolution peripheral quantitative computed tomography (HR‐pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding of fracture susceptibility. Women with (n = 68) and without (n = 101) a history of postmenopausal fragility fracture had aBMD measured by DXA and trabecular and cortical vBMD and trabecular microarchitecture of the radius and tibia measured by HR‐pQCT. Finite‐element analysis (FEA) of HR‐pQCT scans was performed to estimate bone stiffness. DXA T‐scores were similar in women with and without fracture at the spine, hip, and one‐third radius but lower in patients with fracture at the ultradistal radius (p < .01). At the radius fracture, patients had lower total density, cortical thickness, trabecular density, number, thickness, higher trabecular separation and network heterogeneity (p < .0001 to .04). At the tibia, total, cortical, and trabecular density and cortical and trabecular thickness were lower in fracture patients (p < .0001 to .03). The differences between groups were greater at the radius than at the tibia for inner trabecular density, number, trabecular separation, and network heterogeneity (p < .01 to .05). Stiffness was reduced in fracture patients, more markedly at the radius (41% to 44%) than at the tibia (15% to 20%). Women with fractures had reduced vBMD, microarchitectural deterioration, and decreased strength. These differences were more prominent at the radius than at the tibia. HR‐pQCT and FEA measurements of peripheral sites are associated with fracture prevalence and may increase understanding of the role of microarchitectural deterioration in fracture susceptibility. © 2010 American Society for Bone and Mineral Research.
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.152
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3149820
Format
–
Schlagworte
Absorptiometry, Photon
,
Aged
,
Biological and medical sciences
,
Biomechanical Phenomena
,
Bone Density
,
Female
,
Finite Element Analysis
,
FRACTURE
,
Fractures, Bone - diagnostic imaging
,
Fractures, Bone - pathology
,
Fractures, Bone - physiopathology
,
Fundamental and applied biological sciences. Psychology
,
Humans
,
MICROARCHITECTURE
,
Middle Aged
,
Original
,
OSTEOPOROSIS
,
POSTMENOPAUSAL
,
Postmenopause
,
Radius - diagnostic imaging
,
Radius - pathology
,
Radius - physiopathology
,
ROC Curve
,
Skeleton and joints
,
STIFFNESS
,
Tibia - diagnostic imaging
,
Tibia - pathology
,
Tibia - physiopathology
,
Tomography, X-Ray Computed
,
Vertebrates: osteoarticular system, musculoskeletal system
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX