Mayo Clinic proceedings, 2011-08, Vol.86 (8), p.805-817
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Current Concepts in Antifungal Pharmacology
- Ist Teil von
- Mayo Clinic proceedings, 2011-08, Vol.86 (8), p.805-817
- Ort / Verlag
- Rochester, MN: Elsevier Inc
- Erscheinungsjahr
- 2011
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Abstract The introduction of new antifungal agents (eg, echinocandins, second-generation triazoles) in the past decade has transformed the management of invasive mycoses to the point that drug toxicity is no longer the major limiting factor in treatment. Yet, many of these newer antifungal agents have important limitations in their spectrum of activity, pharmacokinetics, and unique predisposition for pharmacokinetic drug-drug interactions and unusual toxicities associated with long-term use. This article reviews key pharmacological aspects of systemic antifungal agents as well as evolving strategies, such as pharmacokinetic-pharmacodynamic optimization and therapeutic drug monitoring, to improve the safety and efficacy of systemic antifungal therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0025-6196eISSN: 1942-5546DOI: 10.4065/mcp.2011.0247Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3146381
- Format
- –
- Schlagworte
- Antibiotics. Antiinfectious agents. Antiparasitic agents, Antifungal agents, Antifungal Agents - adverse effects, Antifungal Agents - pharmacokinetics, Antifungal Agents - pharmacology, Antifungal Agents - therapeutic use, Biological and medical sciences, Care and treatment, Drug interactions, Drug Monitoring, Drug Resistance, Fungal, Drug Resistance, Multiple, Fungal, Drug therapy, Fungi - drug effects, General aspects, Health aspects, Humans, Internal Medicine, Medical sciences, Mycoses, Mycoses - drug therapy, Pharmacology. Drug treatments, Physiological aspects, Symposium on Antimicrobial Therapy