Genes & development, 2011-07, Vol.25 (14), p.1470-1475
2011
Details
- Autor(en) / Beteiligte
- Titel
- Nuclear factor I/B is an oncogene in small cell lung cancer
- Ist Teil von
- Genes & development, 2011-07, Vol.25 (14), p.1470-1475
- Ort / Verlag
- United States: Cold Spring Harbor Laboratory Press
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0890-9369eISSN: 1549-5477DOI: 10.1101/gad.2046711Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3143937
- Format
- –
- Schlagworte
- Animals, Animals, Genetically Modified, Apoptosis, Cell Line, Tumor, Cell Proliferation, Cell Survival - genetics, Cell Transformation, Neoplastic - genetics, Cell Transformation, Neoplastic - metabolism, Disease Models, Animal, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Mice, NFI Transcription Factors - genetics, NFI Transcription Factors - metabolism, Oncogenes - genetics, Oncogenes - physiology, Research Communication, Small Cell Lung Carcinoma - genetics