Details

Autor(en) / Beteiligte

• DeWan, Andrew T., PhD
• Triche, Elizabeth W., PhD
• Xu, Xuming, PhD
• Hsu, Ling-I, MPH
• Zhao, Connie, PhD
• Belanger, Kathleen, PhD
• Hellenbrand, Karen, MPH
• Willis-Owen, Saffron A.G., PhD
• Moffatt, Miriam, PhD
• Cookson, William O.C., MD, PhD
• Himes, Blanca E., PhD
• Weiss, Scott T., MD
• Gauderman, W. James, PhD
• Baurley, James W., MS
• Gilliland, Frank, MD, PhD
• Wilk, Jemma B., DSc
• O’Connor, George T., MD
• Strachan, David P., PhD
• Hoh, Josephine, PhD
• Bracken, Michael B., PhD

Titel

PDE11A associations with asthma: Results of a genome-wide association scan

Ist Teil von

• Journal of allergy and clinical immunology, 2010-10, Vol.126 (4), p.871-873.e9

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Furthermore, we examined the evidence for association to SNPs within PDE11A in 5 independent case/control populations, of which 3 had at least 1 SNP with a nominally significant P value.\n1 295 59.6 Yes 32 48.5 21 51.2 56 54.9 200 40.4 Sibling asthma         None 27 40.9 23 54.8 44 44.9 386 77.5 1 or more 39 59.1 19 45.2 54 55.1 112 22.5 Sex         Male 37 66.1 17 47.2 57 65.5 210 45.8 Female 19 33.9 19 52.8 30 34.5 248 54.2 [low *] Demographic and phenotype data      GWAS All PRAM rs # Chromosome Position Gene Risk allele Allelic[low *] Genotypic[low *] ORhom (95% CI) ORhet (95%CI) Allelic[low *] Genotypic[low *] ORhom (95% CI) ORhet (95%CI) Selection rs710235 1 41975301 HIVEP3 G 1.78E-05 2.15E-03 12.7 (1.6-101.7) 3.7 (1.1-12.0) -- -- -- -- GWAS rs4284254[dagger] 1 41985663 HIVEP3 G 1.98E-06 4.16E-04 12.7 (1.6-101.7) 7.3 (1.6-34.2) -- -- -- -- GWAS rs7517484 1 42023043 HIVEP3 C 3.16E-06 1.98E-04 11.3 (1.4-91.8) 8.7 (1.9-40.4) -- -- -- -- GWAS rs1154799[double dagger] 3 125584866 KALRN C 1.04E-04 3.55E-05 6.6§ (2.7-16.4) -- 1.25E-02 3.99E-02 3.5 (0.5-27.1) 1.9 (0.2-15.4) GWAS rs9832203 3 125585007 KALRN A 1.26E-04 9.88E-05 5.6§ (2.3-13.6) -- -- -- -- -- GWAS rs7216389[double dagger] 17 35323475 ORMDL3 T 7.67E-01 7.40E-01 1.0 (0.3-3.9) 0.7 (0.2-2.6) 2.40E-01 2.97E-01 1.4 (0.7-2.5) 0.9 (0.5-1.7) Candidate [low *] Information on additional top and candidate SNPs genotyped in PRAM children ORhet, Odds ratio comparing the heterozygous risk genotype to the homozygous wild-type genotype; ORhom, odds ratio comparing the homozygous risk genotype to the homozygous wild-type genotype.- Indicates that these SNPs were not genotyped in the All PRAM samples.