Details

Autor(en) / Beteiligte

• Joeckel, L T
• Wallich, R
• Martin, P
• Sanchez-Martinez, D
• Weber, F C
• Martin, S F
• Borner, C
• Pardo, J
• Froelich, C
• Simon, M M

Titel

Mouse granzyme K has pro-inflammatory potential

Ist Teil von

• Cell death and differentiation, 2011-07, Vol.18 (7), p.1112-1119

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infected wild-type (wt) and gzm A/B-deficient mice express similar levels of gzmK protein, with both mouse strains efficiently controlling infection. GzmK, in recombinant form or secreted by ex vivo-derived LCMV-immune gzmAxB(-/-) Tc cells, lacks pro-apoptotic activity. Instead, gzmK induces primary mouse macrophages to process and secrete interleukin-1β, independent of the ATP receptor P2X(7). Together with the finding that IL-1Ra (Anakinra) treatment inhibits virus elimination but not generation of cytotoxic Tc cells in wt mice, the data suggest that Tc cells control LCMV through non-cytotoxic processes that involve gzmK.