Details

Autor(en) / Beteiligte

• Rainbow, Daniel B.
• Moule, Carolyn
• Fraser, Heather I.
• Clark, Jan
• Howlett, Sarah K.
• Burren, Oliver
• Christensen, Mikkel
• Moody, Val
• Steward, Charles A.
• Mohammed, Javid P.
• Fusakio, Michael E.
• Masteller, Emma L.
• Finger, Erik B.
• Houchins, J. P.
• Naf, Dieter
• Koentgen, Frank
• Ridgway, William M.
• Todd, John A.
• Bluestone, Jeffrey A.
• Peterson, Laurence B.
• Mattner, Jochen
• Wicker, Linda S.

Titel

Evidence that Cd101 is an autoimmune diabetes gene in NOD mice

Ist Teil von

• The Journal of immunology (1950), 2011-05, Vol.187 (1), p.325-336

Erscheinungsjahr

2011

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 (B6) mice accounts for the protection from type 1 diabetes (T1D) provided by the Idd10 region, a <1 Mb region on mouse chromosome 3. Here, we provide further support for the hypothesis that Cd101 is Idd10 using haplotype and expression analyses of novel Idd10 congenic strains coupled to the development of a CD101 knockout mouse. Susceptibility to T1D was correlated with genotype-dependent CD101 expression on multiple cell subsets, including FoxP3 + regulatory CD4 + T cells, CD11c + dendritic cells and Gr1 + myeloid cells. The correlation of CD101 expression on immune cells from four independent Idd10 haplotypes with the development of T1D supports the identity of Cd101 as Idd10 . Since CD101 has been associated with T regulatory and antigen presentation cell functions, our results provide a further link between immune regulation and susceptibility to T1D.