Details

Autor(en) / Beteiligte

• Villacres, Maria C
• Literat, Oana
• Degiacomo, Marina
• Du, Wenbo
• La Rosa, Corinna
• Diamond, Don J
• Kovacs, Andrea

Titel

Reduced type 1 and type 2 cytokines in antiviral memory T helper function among women coinfected with HIV and HCV

Ist Teil von

• Journal of clinical immunology, 2005-03, Vol.25 (2), p.134-141

Ort / Verlag

Netherlands: Springer Nature B.V

Erscheinungsjahr

2005

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared to women with single HIV or HCV infection. The T helper response to HIV, HCV and cytomegalovirus (CMV) as a positive viral control was dominated by type 1 cytokines (interleukin- [IL] 2, interferon- [IFN] gamma and tumor necrosis factor- [TNF] alpha), with IFN-gamma as the most abundantly secreted. IL-4, IL-5 and IL-10 were low in healthy controls and patients. Robust CMV-specific responses contrasted with curtailed HCV-specific responses in HCV-infected women. The overall anti-viral profile was dominated by Th1 cytokines even in coinfected women but both type 1 and type 2 responses were reduced in HIV-infected women and more extensively in women with HCV/HIV coinfection.