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MicroRNA‐137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck
Cancer, 2011-04, Vol.117 (7), p.1454-1462
Langevin, Scott M.
Stone, Roslyn A.
Bunker, Clareann H.
Lyons‐Weiler, Maureen A.
LaFramboise, William A.
Kelly, Lori
Seethala, Raja R.
Grandis, Jennifer R.
Sobol, Robert W.
Taioli, Emanuela
2011
Details
Autor(en) / Beteiligte
Langevin, Scott M.
Stone, Roslyn A.
Bunker, Clareann H.
Lyons‐Weiler, Maureen A.
LaFramboise, William A.
Kelly, Lori
Seethala, Raja R.
Grandis, Jennifer R.
Sobol, Robert W.
Taioli, Emanuela
Titel
MicroRNA‐137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck
Ist Teil von
Cancer, 2011-04, Vol.117 (7), p.1454-1462
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND: The overall 5‐year survival rate of approximately 60% for head and neck cancer patients has remained essentially unchanged over the past 30 years. MicroRNA‐137 (miR‐137) plays an essential role in cell‐cycle control at the G1/S‐phase checkpoint. However, the aberrant miR‐137 promoter methylation observed in squamous cell carcinoma of the head and neck (SCCHN) suggests a tumor‐specific molecular defect that may contribute to disease progression. METHODS: The goal of this study was to assess, in formalin‐fixed, paraffin‐embedded tumor tissue, the association between miR‐137 promoter methylation and survival (both overall and disease free) and with prognostic factors including stage, tumor size, lymph node positivity, tumor grade, and surgical tumor margin positivity. RESULTS: The promoter methylation status of miR‐137 was ascertained by methylation‐specific polymerase chain reaction and detected in 11 of 67 SCCHN patients (16.4%), with no significant differences according to site (oral cavity, pharynx, larynx). Methylation of the miR‐137 promoter was significantly associated with overall survival (hazard ratio, 3.68; 95% confidence interval, 1.01‐13.38) but not with disease‐free survival or any of the prognostic factors evaluated. CONCLUSIONS: The results of this study indicate that miR‐137 is methylated in tumor tissue from pharyngeal and laryngeal squamous cancers, in addition to oral squamous cell carcinoma, and that miR‐137 promoter methylation has potential utility as a prognostic marker for SCCHN. Cancer 2011. © 2010 American Cancer Society. MicroRNA‐137 promoter methylation was detected in squamous cell carcinoma of the head and neck across all sites. Methylation‐positive tumor tissue was associated with poorer overall survival.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X, 1097-0142
eISSN: 1097-0142
DOI: 10.1002/cncr.25689
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3117118
Format
–
Schlagworte
Biological and medical sciences
,
Carcinoma, Squamous Cell - genetics
,
Carcinoma, Squamous Cell - mortality
,
Cell survival
,
Disease-Free Survival
,
DNA Methylation
,
epigenetics
,
Female
,
head and neck cancer
,
Head and Neck Neoplasms - genetics
,
Head and Neck Neoplasms - mortality
,
Humans
,
Male
,
Medical sciences
,
MicroRNAs - analysis
,
Middle Aged
,
miRNA
,
miR‐137
,
Otorhinolaryngology (head neck, general aspects and miscellaneous)
,
Otorhinolaryngology. Stomatology
,
Prognosis
,
Promoter Regions, Genetic
,
Tumors
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