Details

Autor(en) / Beteiligte

• Fardelone, Lucídio C.
• Rodrigues, J. Augusto R.
• Moran, Paulo J. S.
• Dekker, Robert F. H.

Titel

Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182

Ist Teil von

• Enzyme Research, 2011, Vol.2011 (2011), p.1055-1062

Ort / Verlag

Cairo, Egypt: Hindawi Limiteds

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Enantioselective reductions of p-R1-C6H4C(O)CH2R2 (R1 = Cl, Br, CH3, OCH3, NO2 and R2 = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries.