Atherosclerosis, 2011-06, Vol.216 (2), p.321-326
2011
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- Autor(en) / Beteiligte
- Titel
- Role for Nox1 NADPH oxidase in atherosclerosis
- Ist Teil von
- Atherosclerosis, 2011-06, Vol.216 (2), p.321-326
- Ort / Verlag
- Amsterdam: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Objective Examine the contribution of Nox1 NADPH oxidase to atherogenesis. Methods and results Male apolipoprotein E deficient mice (ApoE−/− ) and male mice deficient in both apolipoprotein E and Nox1 (ApoE−/− Nox1−/y ) received an atherogenic diet for 18 weeks. Mean blood pressures, body weights, and serum cholesterol levels were similar between the two groups of mice. Deficiency of Nox1 decreased superoxide levels and reduced lesion area in the aortic arch from 43% (ApoE−/− ) to 28% (ApoE−/− Nox1−/y ). The reduction in lesion size at the level of the aortic valve in ApoE−/− /Nox1−/y was accompanied by a decrease in macrophage infiltration as compared to ApoE−/− mice. Carotid artery ligation in ApoE−/− mice induced accelerated intimal hyperplasia with decreased cellular proliferation and increased collagen content in the neointima of vessels deficient in Nox1. Conclusions Nox1-derived ROS modify lesion composition and contribute to lesion size in a murine model of atherosclerosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9150eISSN: 1879-1484DOI: 10.1016/j.atherosclerosis.2011.02.028Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3110523
- Format
- –
- Schlagworte
- animal models, Animals, Aorta, Thoracic - pathology, apolipoprotein E, Apolipoproteins E - genetics, Associated diseases and complications, atherogenesis, Atherosclerosis, Atherosclerosis (general aspects, experimental research), Atherosclerosis - enzymology, Atherosclerosis - physiopathology, Biological and medical sciences, Blood and lymphatic vessels, blood pressure, blood serum, body weight, Cardiology. Vascular system, Cardiovascular, carotid arteries, Carotid Arteries - surgery, Cell Proliferation, cholesterol, Cholesterol - metabolism, collagen, Collagen - metabolism, Diabetes. Impaired glucose tolerance, diet, Diet, Atherogenic, Disease Models, Animal, Endocrine pancreas. Apud cells (diseases), Endocrinopathies, Female, hyperplasia, Hyperplasia - pathology, macrophages, Male, Medical sciences, Mice, Mice, Inbred C57BL, Mice, Transgenic, NADH, NADPH Oxidoreductases - genetics, NADH, NADPH Oxidoreductases - physiology, NADP (coenzyme), NADPH oxidase, NADPH Oxidase 1, Oxidative stress, Superoxides - chemistry