Nature (London), 2010-12, Vol.468 (7324), p.691-695
2010
Details
- Autor(en) / Beteiligte
- Titel
- Acid sensing by the Drosophila olfactory system
- Ist Teil von
- Nature (London), 2010-12, Vol.468 (7324), p.691-695
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- Psychology & Behavioral Sciences Collection
- Beschreibungen/Notizen
- The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors. In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836, 1476-4687eISSN: 1476-4687DOI: 10.1038/nature09537Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3105465
- Format
- –
- Schlagworte
- Acetic Acid, Acetic Acid - analysis, Acetic Acid - pharmacology, Acidity, Acids, Acids - analysis, Acids - pharmacology, Animals, Arthropod Antennae, Arthropod Antennae - anatomy & histology, Arthropod Antennae - cytology, Arthropod Antennae - drug effects, Arthropod Antennae - innervation, Calcium Signaling, Calcium Signaling - drug effects, Carbon Dioxide, Carbon Dioxide - metabolism, Carbonic Acid, Carbonic Acid - metabolism, Carbonic Acid - pharmacology, Cellular biology, Drosophila, Drosophila melanogaster, Drosophila melanogaster - anatomy & histology, Drosophila melanogaster - cytology, Drosophila melanogaster - drug effects, Drosophila melanogaster - physiology, Drosophila Proteins, Drosophila Proteins - metabolism, Food and Nutrition, Genetic aspects, Insects, Life Sciences, Maze Learning, Molecular biology, Neurons, Odorants - analysis, Odors, Olfactory Pathways, Olfactory Pathways - cytology, Olfactory Pathways - drug effects, Olfactory Pathways - physiology, Pheromones, Physiological aspects, Receptors, Ionotropic Glutamate, Receptors, Ionotropic Glutamate - metabolism, Receptors, Odorant, Receptors, Odorant - metabolism, Rhinencephalon, Sensilla, Sensilla - cytology, Sensory Receptor Cells, Sensory Receptor Cells - drug effects, Sensory Receptor Cells - metabolism, Sensory receptors, Temperature