Details

Autor(en) / Beteiligte

• Díaz-Jiménez, David
• Núñez, Lucía E
• Beltrán, Caroll J
• Candia, Enzo
• Suazo, Cristóbal
• Alvarez-Lobos, Manuel
• González, María-Julieta
• Hermoso, Marcela A
• Quera, Rodrigo

Titel

Soluble ST2：A new and promising activity marker in ulcerative colitis

Ist Teil von

• World journal of gastroenterology : WJG, 2011-05, Vol.17 (17), p.2181-2190

Ort / Verlag

United States: Baishideng Publishing Group Co., Limited

Erscheinungsjahr

2011

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• AIM：To correlate circulating soluble ST2（sST2） levels with the severity of ulcerative colitis（UC） and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS：We recruited 153 patients：82 with UC,26 with Crohn＇s disease（CD） and 43 disease controls [non-inflammatory bowel disease（IBD）].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median（25th-75th）] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls（HC） was determined with regard to sensitivity and specificity,and Spearman＇s rank correlation coefficient（r）.To validate the method,the area under the curve（AUC） of receiver-operator characteristic（ROC） was determined（AUC,95% CI） and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS：The serum sST2 value was significantly higher in patients with active [235.80（90.65-367.90） pg/mL] rather than inactive UC [33.19（20.04-65.32） pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC（P 0.001）.The median level of sST2 in CD patients was 54.17（35.02-122.0） pg/mL,significantly higher than that of the HC group only（P 0.01）.The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92（0.86-0.97,P 0.0001）.The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores（r = 0.76 and r = 0.67,P 0.0001,respectively）,and with the pro-inflammatory cytokine,tumor necrosis factor-α（r = 0.69 and r = 0.61,respectively,P 0.0001）.Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild（r = 0.44,P = 0.004）,moderate（r = 0.59,P = 0.002） and severe disease（r = 0.82,P = 0.002）.Only patients with inactive UC showed no significant correlation（r = 0.45,P = 0.267）.CONCLUSION：sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker.