The American journal of pathology, 2011-02, Vol.178 (2), p.709-717
2011
Details
- Autor(en) / Beteiligte
- Titel
- Differential Distribution and Phenotype of Decidual Macrophages in Preeclamptic versus Control Pregnancies
- Ist Teil von
- The American journal of pathology, 2011-02, Vol.178 (2), p.709-717
- Ort / Verlag
- Bethesda, MD: Elsevier Inc
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Maternal immune tolerance of the semiallogeneic fetus is a complex phenomenon. Macrophages are an abundant cell population in the human decidua, and changes in distribution or phenotype may be involved in the development of preeclampsia. The aim of this study was to assess the distribution and phenotype of macrophages in preterm preeclamptic, preterm control, and term control placentas. Placentas of preterm preeclamptic ( n = 6), preterm control ( n = 5), and term control pregnancies ( n = 6) were sequentially immunohistochemically stained for CD14, CD163, DC SIGN, and IL-10. The distributions of CD14+ , CD163+ , DC SIGN+ , IL-10+ , CD163+ /CD14+ , DC SIGN+ /CD14+ , and Flt-1/CD14+ cells were determined by double staining and by digital image analysis of sequential photomicrographs. CD14 and CD163 expression increased significantly in preterm preeclamptic decidua basalis compared with preterm control pregnancies ( P = 0.0006 and P = 0.034, respectively). IL-10 expression was significantly lower in the decidua parietalis of preterm preeclamptic pregnancies compared with preterm control pregnancies ( P = 0.03). The CD163/CD14 ratio was significantly lower in the decidua basalis ( P = 0.0293) and the DC SIGN/CD14 ratio was significantly higher in the decidua basalis ( P < 0.0001) and parietalis ( P < 0.0001) of preterm preeclamptic pregnancies compared with preterm control pregnancies. CD14+ macrophages did express Flt-1. Alterations in distribution and phenotype of macrophages in the decidua of preterm preeclamptic pregnancies compared with control pregnancies may contribute to the pathogenesis of preeclampsia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0002-9440eISSN: 1525-2191DOI: 10.1016/j.ajpath.2010.10.011Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3069820
- Format
- –
- Schlagworte
- Adult, Antigens, CD - metabolism, Antigens, Differentiation, Myelomonocytic - metabolism, Biological and medical sciences, Case-Control Studies, Cell Adhesion Molecules - metabolism, Decidua - metabolism, Decidua - pathology, Female, Humans, Immunohistochemistry, Interleukin-10 - metabolism, Investigative techniques, diagnostic techniques (general aspects), Lectins, C-Type - metabolism, Lipopolysaccharide Receptors - metabolism, Macrophages - metabolism, Macrophages - pathology, Medical sciences, Pathology, Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques, Phenotype, Pilot Projects, Pre-Eclampsia - metabolism, Pre-Eclampsia - pathology, Pregnancy, Premature Birth - metabolism, Premature Birth - pathology, Receptors, Cell Surface - metabolism, Regular, Vascular Endothelial Growth Factor Receptor-1 - metabolism