Details

Autor(en) / Beteiligte

• An, Ping
• Winkler, Cheryl
• Guan, Li
• O'Brien, Stephen J.
• Zeng, Zheng

Titel

A Common "HLA-DPA1" Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese

Ist Teil von

• The Journal of infectious diseases, 2011-04, Vol.203 (7), p.943-947

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2011

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA -DP Al rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P = .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.