Environmental health perspectives, 2011-03, Vol.119 (3), p.377-383
2011
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- Autor(en) / Beteiligte
- Titel
- Fate and Complex Pathogenic Effects of Dioxins and Polychlorinated Biphenyls in Obese Subjects before and after Drastic Weight Loss
- Ist Teil von
- Environmental health perspectives, 2011-03, Vol.119 (3), p.377-383
- Ort / Verlag
- Research Triangle Park, NC: National Institute of Environmental Health Sciences
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Background: In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear. Objectives: We characterized POP total body burden and their redistribution in obese individuals before and after drastic weight loss and compared these values with a variety of molecular, biological, and clinical parameters. Methods: Seventy-one obese subjects were enrolled and underwent bariatric surgery. Blood and adipose tissue samples were obtained at different times from these individuals as well as from 18 lean women. Results: POP content (17 dioxins/furans and 18 polychlorinated biphenyi congeners) in different adipose tissue territories was similar, allowing us to assess total POP body burden from a single biopsy. Total POP body burden was 2 to 3 times higher in obese than in lean individuals. We also found increased expression of some POP target genes in obese adipose tissue. Drastic weight loss led to increased serum POPs and, within 6-12 months, to a significant 15% decrease in total polychlorinated biphenyi body burden. Importantly, serum POP levels were positively correlated with liver toxicity markers and lipid parameters, independently of age and body mass index. Conclusions: POP content in adipose tissue and serum correlate with biological markers of obesityrelated dysfunctions. Drastic weight loss leads to a redistribution of POPs and to a moderate decrease of their total body burden.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-6765eISSN: 1552-9924DOI: 10.1289/ehp.1002848Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3060002
- Format
- –
- Schlagworte
- Adipose Tissue - metabolism, Adipose tissues, Adult, Aryl Hydrocarbon Hydroxylases - genetics, Aryl Hydrocarbon Hydroxylases - metabolism, Biological, Biological and medical sciences, Body Burden, Body fat, Correlation, Cytochrome P-450 CYP1A1 - metabolism, Cytochrome P-450 CYP1B1, Dioxin, Dioxins, Dioxins - metabolism, Dioxins - toxicity, Environment. Living conditions, Environmental Pollutants - metabolism, Environmental Pollutants - toxicity, Female, Humans, Life Sciences, Lipid metabolism, Lipids, Liver, Male, Markers, Medical sciences, Metabolic diseases, Middle Aged, NAD(P)H Dehydrogenase (Quinone) - genetics, NAD(P)H Dehydrogenase (Quinone) - metabolism, Obesity, Obesity - blood, Obesity - metabolism, Obesity - pathology, Persistent organic pollutants, Physiological aspects, Pollutants, Polychlorinated biphenyls, Polychlorinated Biphenyls - metabolism, Polychlorinated Biphenyls - toxicity, Public health. Hygiene, Public health. Hygiene-occupational medicine, Serums, Toxicity, Toxicology, Weight Loss