Biological psychiatry (1969), 2009-05, Vol.65 (9), p.760-769
2009
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene
- Ist Teil von
- Biological psychiatry (1969), 2009-05, Vol.65 (9), p.760-769
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Background Childhood maltreatment and early trauma leave lasting imprints on neural mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver, we investigated whether early-life adversity leaves lasting epigenetic marks at the brain-derived neurotrophic factor ( BDNF ) gene in the central nervous system. Methods During the first postnatal week, we exposed infant rats to stressed caretakers that predominately displayed abusive behaviors. We then assessed DNA methylation patterns and gene expression throughout the life span as well as DNA methylation patterns in the next generation of infants. Results Early maltreatment produced persisting changes in methylation of BDNF DNA that caused altered BDNF gene expression in the adult prefrontal cortex. Furthermore, we observed altered BDNF DNA methylation in offspring of females that had previously experienced the maltreatment regimen. Conclusions These results highlight an epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-3223eISSN: 1873-2402DOI: 10.1016/j.biopsych.2008.11.028Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3056389
- Format
- –
- Schlagworte
- Animals, Animals, Newborn - genetics, Animals, Newborn - metabolism, BDNF, Biological and medical sciences, Brain-Derived Neurotrophic Factor - genetics, Brain-Derived Neurotrophic Factor - metabolism, Child, child abuse, Cytidine - administration & dosage, Cytidine - analogs & derivatives, Cytidine - pharmacology, DNA methylation, DNA Methylation - drug effects, Epigenesis, Genetic, epigenetics, Female, Gene Expression, hippocampus, Hippocampus - metabolism, Injections, Intraventricular, Male, Maternal Behavior, Medical sciences, Models, Animal, prefrontal cortex, Prefrontal Cortex - metabolism, Psychiatry, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry, Rats, Rats, Long-Evans, Reelin, Stress, Psychological - genetics, transgenerational inheritance, Victimology