Details

Autor(en) / Beteiligte

• Penning, Trevor M.
• Byrns, Michael C.

Titel

Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

Ist Teil von

• Annals of the New York Academy of Sciences, 2009-02, Vol.1155 (1), p.33-42

Ort / Verlag

Malden, USA: Blackwell Publishing Inc

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Prostate and breast cancer are hormone‐dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo‐keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type 5 17β‐HSD) reduces Δ4‐androstene‐3,17‐dione to yield testosterone while AKR1C2 (type 3 3α‐HSD) eliminates 5α‐dihydrotestosterone (5α‐DHT), and AKR1C1 forms 3β‐androstanediol (a ligand for ERβ). In the breast, AKR1C3 forms testosterone, which is converted to 17β‐estradiol by aromatase or reduces estrone to 17β‐estradiol directly. AKR1C3 also acts as a prostaglandin (PG) F synthase and forms PGF2α and 11β‐PGF2α, which stimulate the FP receptor and prevent the activation of PPARγ by PGJ2 ligands. This proproliferative signaling may stimulate the growth of hormone‐dependent and ‐independent prostate and breast cancer.