Details

Autor(en) / Beteiligte

• Storti-Melo, Luciane M
• Souza-Neiras, Wanessa C
• Cassiano, Gustavo C
• Taveira, Leonardo C
• Cordeiro, Antônio J
• Couto, Vanja S C A
• Póvoa, Marinete M
• Cunha, Maristela G
• Echeverry, Diana M
• Rossit, Andréa R B
• Arévalo-Herrera, Myriam
• Herrera, Sócrates
• Machado, Ricardo L D

Titel

Evaluation of the naturally acquired antibody immune response to the Pv200L N-terminal fragment of Plasmodium vivax merozoite surface protein-1 in four areas of the Amazon Region of Brazil

Ist Teil von

• The American journal of tropical medicine and hygiene, 2011-02, Vol.84 (2 Suppl), p.58-63

Ort / Verlag

United States: The American Society of Tropical Medicine and Hygiene

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Frequency and levels of IgG antibodies to an N-terminal fragment of the Plasmodium vivax MSP-1 (Pv200L) protein, in individuals naturally exposed to malaria in four endemic areas of Brazil, were evaluated by enzyme-linked immunosorbent assay. Plasma samples of 261 P. vivax-infected individuals from communities of Macapá, Novo Repartimento, Porto Velho, and Plácido de Castro in the Amazonian region with different malaria transmission intensities. A high mean number of studied individuals (89.3%) presented with antibodies to the Pv200L that correlated with the number of previous malaria infections; there were significant differences in the frequency of the responders (71.9-98.7) and in the antibody levels (1:200-1:51,200) among the four study areas. Results of this study provide evidence that Pv200L is a naturally immunogenic fragment of the PvMSP-1 and is associated with the degree of exposure to parasites. The fine specificity of antibodies to Pv200L is currently being assessed.