Angewandte Chemie International Edition, 2010-12, Vol.49 (52), p.10149-10153
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin
- Ist Teil von
- Angewandte Chemie International Edition, 2010-12, Vol.49 (52), p.10149-10153
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Changing the subject: An efficient linear solid‐phase peptide synthesis of ubiquitin (Ub) has been developed. This approach allows the incorporation of desired tags and mutations (see picture; blue denotes a pseudoproline dipeptide, red a dimethoxybenzyl dipeptide) as well as specific C‐terminal modification and the construction of all diubiquitin conjugates in high yields and purities in a straightforward manner.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.201005995Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3021723
- Format
- –
- Schlagworte
- Amino Acid Sequence, chemical ligation, Communication, Molecular Sequence Data, Mutation, peptides, Peptides - chemical synthesis, Peptides - chemistry, Peptides - genetics, Protein Folding, solid-phase synthesis, synthetic methods, ubiquitin, Ubiquitin - chemical synthesis, Ubiquitin - chemistry, Ubiquitin - genetics