Details

Autor(en) / Beteiligte

• Amagata, Taro
• Morinaka, Brandon I.
• Amagata, Akiko
• Tenney, Karen
• Valeriote, Frederick A.
• Lobkovsky, Emil
• Clardy, Jon
• Crews, Phillip

Titel

A Chemical Study of Three Novel Cyclic Depsipeptides Produced by a Sponge-Derived Fungus

Ist Teil von

• Journal of natural products (Washington, D.C.), 2006-11, Vol.69 (11), p.1560-1565

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Two novel cyclic depsipeptides, guangomides A ( 1 ) and B ( 2 ), together with a new destruxin derivative ( 3 ) were isolated from the cytotoxic extract obtained from the saltwater culture of an unidentified sponge-derived fungus. The new structures were elucidated based on analysis of extensive 1D and 2D NMR data sets, and the absolute configurations of 2 S , 9 S , 13 S , 19 S , 24 R , 28 R of 1 was determined based on the combined X-ray and Marfey's method structure analysis. Identical absolute configurations were assumed for 2 . The cytotoxicity of the extract was found to be due to brefeldin A, while 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans .