Details

Autor(en) / Beteiligte

• Browne, Liam Edward
• Cao, Lishuang
• Broomhead, Helen
• Bragg, Laricia
• Wilkinson, William
• North, R. Alan

Titel

P2X receptor channels show three-fold symmetry in ionic charge selectivity and unitary conductance

Ist Teil von

• Nature neuroscience, 2010-12, Vol.14 (1), p.17-18

Ort / Verlag

Nature Publishing Group

Erscheinungsjahr

2010

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• In the closed structure of the P2X cation channel, three α-helical transmembrane domains cross the membrane obliquely: in rat P2X2 receptors, these intersect at Thr339. Replacing Thr339 by lysine in one, two or three subunits progressively increased chloride permeability and reduced unitary conductance. This implies that the closed-open transition involves a symmetrical separation of the three subunits, and that Thr339 from each contributes symmetrically to the open channel permeation pathway.