Details

Autor(en) / Beteiligte

• Vantourout, Pierre
• Radojkovic, Claudia
• Lichtenstein, Laeticia
• Pons, Véronique
• Champagne, Eric
• Martinez, Laurent O

Titel

Ecto-F₁-ATPase: a moonlighting protein complex and an unexpected apoA-I receptor

Ist Teil von

• World journal of gastroenterology : WJG, 2010-12, Vol.16 (47), p.5925-5935

Ort / Verlag

United States: Baishideng Publishing Group Co., Limited

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Mitochondrial ATP synthase has been recently detected at the surface of different cell types, where it is a high affinity receptor for apoA-I, the major protein component in high density lipoproteins (HDL). Cell surface ATP synthase (namely ecto-F₁-ATPase) expression is related to different biological effects, such as regulation of HDL uptake by hepatocytes, endothelial cell proliferation or antitumor activity of Vγ9/Vδ2 T lymphocytes. This paper reviews the recently discovered functions and regulations of ecto-F₁-ATPase. Particularly, the role of the F₁-ATPase pathway(s) in HDL-cholesterol uptake and apoA-I-mediated endothelial protection suggests its potential importance in reverse cholesterol transport and its regulation might represent a potential therapeutic target for HDL-related therapy for cardiovascular diseases. Therefore, it is timely for us to better understand how this ecto-enzyme and downstream pathways are regulated and to develop pharmacologic interventions.