Details

Autor(en) / Beteiligte

• Joyner, P Matthew
• Liu, Jinman
• Zhang, Zhijun
• Merritt, Justin
• Qi, Fengxia
• Cichewicz, Robert H

Titel

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

Ist Teil von

• Organic & biomolecular chemistry, 2010-01, Vol.8 (24), p.5486-5489

Ort / Verlag

England

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.