Details
- Autor(en) / Beteiligte
- Titel
- Generation of cloned transgenic pigs rich in omega-3 fatty acids
- Ist Teil von
- Nature biotechnology, 2006-04, Vol.24 (4), p.435-436
- Ort / Verlag
- New York, NY: Nature
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1087-0156eISSN: 1546-1696DOI: 10.1038/nbt1198Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2976610
- Format
- –
- Schlagworte
- Animals, Animals, Genetically Modified - metabolism, Biological and medical sciences, Biotechnology, Caenorhabditis elegans, Cloning, Cloning, Organism - methods, fatty acid composition, Fatty acids, Fatty Acids, Omega-3 - genetics, Fatty Acids, Omega-3 - metabolism, Fundamental and applied biological sciences. Psychology, gene expression, Genetic engineering, Genetic technics, Hogs, Humans, lipogenesis, Meat, Meat - analysis, Methods. Procedures. Technologies, Muscle, Skeletal - metabolism, omega-3 fatty acids, omega-6 fatty acids, Protein Engineering - methods, stearoyl-CoA desaturase, Swine, Swine - physiology, Tissue Distribution, transgenes, Transgenic animals, Transgenic animals and transgenic plants