The Journal of clinical investigation, 2010-11, Vol.120 (11), p.3760-3772
2010
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Nociceptors: the sensors of the pain pathway
- Ist Teil von
- The Journal of clinical investigation, 2010-11, Vol.120 (11), p.3760-3772
- Ort / Verlag
- United States: American Society for Clinical Investigation
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers. The activation of functionally distinct cutaneous nociceptor populations and the processing of information they convey provide a rich diversity of pain qualities. Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9738eISSN: 1558-8238DOI: 10.1172/jci42843Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2964977
- Format
- –
- Schlagworte
- Adenosine triphosphatase, Analgesics, Analysis, Animals, Biomedical research, Blood vessels, Care and treatment, Dilatation, GABA, Genetic aspects, Genetic engineering, Health aspects, Heat, Histamine, Hot Temperature, Humans, Ion Channels - metabolism, Mechanotransduction, Cellular - physiology, Nervous System - anatomy & histology, Nervous System - metabolism, Nociceptors, Nociceptors - cytology, Nociceptors - physiology, Pain, Pain - drug therapy, Pain - metabolism, Pain - physiopathology, Pain Threshold - physiology, Primates, Prostaglandins E, Review, Sensation - physiology, Signal Transduction - physiology, Skin, Temperature