Trends in microbiology (Regular ed.), 2010-09, Vol.18 (9), p.388-396
2010
Details
- Autor(en) / Beteiligte
- Titel
- BST-2/tetherin: a new component of the innate immune response to enveloped viruses
- Ist Teil von
- Trends in microbiology (Regular ed.), 2010-09, Vol.18 (9), p.388-396
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to degrade BST-2 and/or direct it away from its site of action at the cell surface. Viral antagonism has subjected BST-2 to positive selection, leading to species-specific differences that presented a barrier to the transmission of simian immunodeficiency viruses (SIVs) to humans. This barrier was crossed by HIV-1 when its Vpu protein acquired activity as a BST-2 antagonist. Here, we review this new host–pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0966-842XeISSN: 1878-4380DOI: 10.1016/j.tim.2010.06.010Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2956607
- Format
- –
- Schlagworte
- Acquired Immunodeficiency Syndrome - epidemiology, Acquired Immunodeficiency Syndrome - virology, Animals, Antigens, CD - chemistry, Antigens, CD - immunology, Antigens, CD - metabolism, Arenavirus, Cell Membrane - immunology, Cell Membrane - virology, Evolution, Molecular, Filovirus, GPI-Linked Proteins, Herpesvirus, HIV-1 - immunology, HIV-1 - metabolism, HIV-1 - physiology, Host-Pathogen Interactions, Human immunodeficiency virus 1, Human Immunodeficiency Virus Proteins - metabolism, Humans, Immunity, Innate, Internal Medicine, Lentivirus, Lentiviruses, Primate - genetics, Lentiviruses, Primate - immunology, Lentiviruses, Primate - physiology, Membrane Glycoproteins - antagonists & inhibitors, Membrane Glycoproteins - chemistry, Membrane Glycoproteins - metabolism, Primates, Retrovirus, Simian immunodeficiency virus, Simian Immunodeficiency Virus - physiology, Viral Envelope Proteins - immunology, Viral Envelope Proteins - metabolism, Viral Regulatory and Accessory Proteins - metabolism