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BibTeX
Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder
Depression and anxiety, 2010-07, Vol.27 (7), p.643-651
Britton, Jennifer C.
Stewart, S. Evelyn
Killgore, William D.S.
Rosso, Isabelle M.
Price, Lauren M.
Gold, Andrea L.
Pine, Daniel S.
Wilhelm, Sabine
Jenike, Michael A.
Rauch, Scott L.
2010
Details
Autor(en) / Beteiligte
Britton, Jennifer C.
Stewart, S. Evelyn
Killgore, William D.S.
Rosso, Isabelle M.
Price, Lauren M.
Gold, Andrea L.
Pine, Daniel S.
Wilhelm, Sabine
Jenike, Michael A.
Rauch, Scott L.
Titel
Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder
Ist Teil von
Depression and anxiety, 2010-07, Vol.27 (7), p.643-651
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Psychology & Behavioral Sciences Collection
Beschreibungen/Notizen
Background: Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive–compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916–920]. Methods: In the current event‐related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N=12) and a HC sample (N=17) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. Results: Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. Conclusions: Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific. Depression and Anxiety, 2010. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1091-4269, 1520-6394
eISSN: 1520-6394
DOI: 10.1002/da.20718
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2951127
Format
–
Schlagworte
Amygdala
,
Amygdala - physiopathology
,
Anxiety
,
anxiety disorder
,
Child
,
Children
,
Depression
,
disgust
,
Emotions
,
Facial Expression
,
fear
,
Female
,
fMRI
,
Functional magnetic resonance imaging
,
Hippocampus
,
Hippocampus - physiopathology
,
Humans
,
Magnetic Resonance Imaging
,
Male
,
neuroimaging
,
Obsessive compulsive disorder
,
Obsessive-Compulsive Disorder - physiopathology
,
OCD
,
Pediatrics
,
Psychiatry
,
Sex Factors
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