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Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease
Movement disorders, 2010-07, Vol.25 (9), p.1246-1252
Josephs, Keith A.
Whitwell, Jennifer L.
Boeve, Bradley F.
Knopman, David S.
Petersen, Ronald C.
Hu, William T.
Parisi, Joseph E.
Dickson, Dennis W.
Jack Jr, Clifford R.
2010
Details
Autor(en) / Beteiligte
Josephs, Keith A.
Whitwell, Jennifer L.
Boeve, Bradley F.
Knopman, David S.
Petersen, Ronald C.
Hu, William T.
Parisi, Joseph E.
Dickson, Dennis W.
Jack Jr, Clifford R.
Titel
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease
Ist Teil von
Movement disorders, 2010-07, Vol.25 (9), p.1246-1252
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
We compare patterns of gray matter loss on MRI in subjects presenting as corticobasal syndrome (CBS) with Alzheimer disease pathology (CBS‐AD) to those presenting as CBS with corticobasal degeneration pathology (CBS‐CBD). Voxel‐based morphometry was used to compare patterns of gray matter loss in pathologically confirmed CBS‐AD subjects (n = 5) and CBS‐CBD subjects (n = 6) to a group of healthy controls (n = 20), and to each other. Atlas based parcellation using the automated anatomic labeling atlas was also utilized in a region‐of‐interest analysis to account for laterality. The CBS‐AD subjects were younger at the time of scan when compared with CBS‐CBD subjects (median: 60 years vs. 69; P = 0.04). After adjusting for age at time of MRI scan, the CBS‐AD subjects showed loss in posterior frontal, temporal, and superior and inferior parietal lobes, while CBS‐CBD showed more focal loss predominantly in the posterior frontal lobes when compared with controls. In both CBS‐AD and CBS‐CBD groups, there was basal ganglia volume loss, yet relative sparing of hippocampi. On direct comparisons between the two subject groups, CBS‐AD showed greater loss in both temporal and inferior parietal cortices than CBS‐CBD. No regions showed greater loss in the CBS‐CBD group compared to the CBS‐AD group. These findings persisted when laterality was taken into account. In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology. © 2010 Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.23062
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2921765
Format
–
Schlagworte
Aged
,
Alzheimer Disease - pathology
,
Alzheimer's disease
,
Basal Ganglia - pathology
,
Basal Ganglia Diseases - pathology
,
Biological and medical sciences
,
Brain Mapping
,
Cerebral Cortex - pathology
,
corticobasal degeneration
,
corticobasal syndrome
,
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
,
Female
,
Humans
,
Imaging, Three-Dimensional - methods
,
Magnetic Resonance Imaging - methods
,
Male
,
Medical sciences
,
Middle Aged
,
Neurology
,
Neuropsychological Tests
,
region-of-interest
,
Retrospective Studies
,
voxel-based morphometry
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