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Genesis of teratogen-induced holoprosencephaly in mice
American journal of medical genetics. Part C, Seminars in medical genetics, 2010-02, Vol.154C (1), p.29-42
Lipinski, Robert J.
Godin, Elizabeth A.
O'leary-Moore, Shonagh K.
Parnell, Scott E.
Sulik, Kathleen K.
2010
Details
Autor(en) / Beteiligte
Lipinski, Robert J.
Godin, Elizabeth A.
O'leary-Moore, Shonagh K.
Parnell, Scott E.
Sulik, Kathleen K.
Titel
Genesis of teratogen-induced holoprosencephaly in mice
Ist Teil von
American journal of medical genetics. Part C, Seminars in medical genetics, 2010-02, Vol.154C (1), p.29-42
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Evidence from mechanical, teratological, and genetic experimentation demonstrates that holoprosencephaly (HPE) typically results from insult prior to the time that neural tube closure is completed and occurs as a consequence of direct or indirect insult to the rostral prechordal cells that induce the forebrain or insult to the median forebrain tissue, itself. Here, we provide an overview of normal embryonic morphogenesis during the critical window for HPE induction, focusing on the morphology and positional relationship of the developing brain and subjacent prechordal plate and prechordal mesoderm cell populations. Subsequent morphogenesis of the HPE spectrum is then examined in selected teratogenesis mouse models. The temporal profile of Sonic Hedgehog expression in rostral embryonic cell populations and evidence for direct or indirect perturbation of the Hedgehog pathway by teratogenic agents in the genesis of HPE is highlighted. Emerging opportunities based on recent insights and new techniques to further characterize the mechanisms and pathogenesis of HPE are discussed. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4868
eISSN: 1552-4876
DOI: 10.1002/ajmg.c.30239
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2914459
Format
–
Schlagworte
Animals
,
Computer Simulation
,
Disease Models, Animal
,
Embryo, Mammalian - pathology
,
Embryo, Mammalian - ultrastructure
,
Embryonic Development - physiology
,
Female
,
Gestational Age
,
holoprosencephaly
,
Holoprosencephaly - chemically induced
,
Holoprosencephaly - embryology
,
Holoprosencephaly - pathology
,
Mice
,
mouse
,
prechordal plate
,
Pregnancy
,
teratogenesis
,
Teratogens
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