Details

Autor(en) / Beteiligte

• Nagy, György
• Koncz, Agnes
• Telarico, Tiffany
• Fernandez, David
• Érsek, Barbara
• Buzás, Edit
• Perl, András

Titel

Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus

Ist Teil von

• Arthritis research & therapy, 2010-01, Vol.12 (3), p.210-210

Ort / Verlag

BioMed Central Ltd

Erscheinungsjahr

2010

Link zum Volltext

Quelle

SpringerNature Journals

Beschreibungen/Notizen

• Nitric oxide (NO) has been shown to regulate T cell functions under physiological conditions, but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue injury has been implicated in a variety of rheumatic diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Several studies reported increased endogenous NO synthesis in both SLE and RA, and recent evidence suggests that NO contributes to T cell dysfunction in both autoimmune diseases. The depletion of intracellular glutathlone may be a key factor predisposing patients with SLE to mitochondrial dysfunction, characterized by mitochondrial hyperpolarization, ATP depletion and predisposition to death by necrosis. Thus, changes in glutathione metabolism may influence the effect of increased NO production in the pathogenesis of autoimmunity.