World journal of gastroenterology : WJG, 2010-06, Vol.16 (23), p.2873-2880
2010
Details
- Autor(en) / Beteiligte
- Titel
- CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis
- Ist Teil von
- World journal of gastroenterology : WJG, 2010-06, Vol.16 (23), p.2873-2880
- Ort / Verlag
- United States: Department of Gastroenterology and Hepatology, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium(DSS)-induced colitis in mice.METHODS:Experimental colitis was induced by administration of 5% DSS for 7 d,and assays performed on intestinal segments from the ileocecal valve to the anus.Colonic morphology was examined by hematoxylin and eosin staining.Colonic cytokines were determined by enzyme-linked immunosorbent ...
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1007-9327eISSN: 2219-2840DOI: 10.3748/wjg.v16.i23.2873Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2887582
- Format
- –
- Schlagworte
- Animals, Apoptosis - drug effects, Cell Movement - drug effects, Colitis - chemically induced, Colitis - drug therapy, Colitis - pathology, Colitis - physiopathology, Colon - drug effects, Colon - pathology, Colon - physiopathology, Cytokines - metabolism, Dextran Sulfate - toxicity, Female, Heterocyclic Compounds - pharmacology, In Vitro Techniques, Inflammation Mediators - metabolism, Leukocytes, Mononuclear - drug effects, Leukocytes, Mononuclear - physiology, Mice, Mice, Inbred BALB C, Original, Permeability - drug effects, Peroxidase - metabolism, Receptors, CXCR4 - antagonists & inhibitors