Details

Autor(en) / Beteiligte

• Wu, Yadi
• Deng, Jiong
• Rychahou, Piotr G.
• Qiu, Suimin
• Evers, B. Mark
• Zhou, Binhua P.

Titel

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

Ist Teil von

• Cancer cell, 2009-05, Vol.15 (5), p.416-428

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2009

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The increased motility and invasiveness of tumor cells are reminiscent of epithelial-mesenchymal transition (EMT), which occurs during embryonic development, wound healing, and metastasis. In this study, we found that Snail is stabilized by the inflammatory cytokine TNFα through the activation of the NF-κB pathway. We demonstrated that NF-κB is required for the induction of COP9 signalosome 2 (CSN2), which, in turn, blocks the ubiquitination and degradation of Snail. Furthermore, we showed that the expression of Snail correlated with the activation of NF-κB in cancer cell lines and metastatic tumor samples. Knockdown of Snail expression inhibited cell migration and invasion induced by inflammatory cytokines and suppressed inflammation-mediated breast cancer metastasis. Our study provides a plausible mechanism for inflammation-induced metastasis.