Details

Autor(en) / Beteiligte

• Knudsen, Karen E
• Penning, Trevor M

Titel

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

Ist Teil von

• Trends in endocrinology and metabolism, 2010-05, Vol.21 (5), p.315-324

Ort / Verlag

Cambridge, MA: Elsevier Ltd

Erscheinungsjahr

2010

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Prostate cancer remains a leading cause of cancer death, as there are no durable means to treat advanced disease. Treatment of non-organ-confined prostate cancer hinges on its androgen dependence. First-line therapeutic strategies suppress androgen receptor (AR) activity, via androgen ablation and direct AR antagonists, whereas initially effective, incurable, ‘castration-resistant’ tumors arise as a result of resurgent AR activity. Alterations of AR and/or associated regulatory networks are known to restore receptor activity and support resultant therapy-resistant tumor progression. However, recent evidence also reveals an unexpected contribution of the AR ligand, indicating that alterations in pathways controlling androgen synthesis support castration-resistant AR activity. In this report, the mechanisms underlying the lethal pairing of AR deregulation and aberrant androgen synthesis in prostate cancer progression will be discussed.