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BDNF+/− mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain
Glia, 2010-05, Vol.58 (7), p.848-856
Vondran, Melissa W.
Clinton-Luke, Patricia
Honeywell, Jean Z.
Dreyfus, Cheryl F.
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Vondran, Melissa W.
Clinton-Luke, Patricia
Honeywell, Jean Z.
Dreyfus, Cheryl F.
Titel
BDNF+/− mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain
Ist Teil von
Glia, 2010-05, Vol.58 (7), p.848-856
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Previous work indicated that brain‐derived neurotrophic factor (BDNF), through the trkB receptor, increases DNA synthesis in oligodendrocyte (OLG) progenitor cells (OPCs) and differentiation of postmitotic OLGs of the basal forebrain (BF). In the present studies, BDNF knockout animals were used to investigate BDNF's effects on OLG lineage cells (OLCs) in vivo. OLCs of the BF were found to express the trkB receptor, suggesting they are responsive to BDNF. Immunohistochemistry using NG2 and CC1 antibodies was utilized to examine the numbers of NG2+ OPCs and CC1+ postmitotic BF OLGs. At embryonic day 17 (E17), BDNF−/− animals display reduced NG2+ cells. This reduction was also observed in BDNF+/− mice at E17 and at postnatal day 1 (P1), P14, and adult stage, suggesting that BDNF plays a role in OPC development. BDNF+/− mice do not exhibit deficits in numbers of CC1+ OLGs. However, myelin basic protein, myelin associated glycoprotein, and proteolipid protein are reduced in BDNF+/− mice, suggesting that BDNF plays a role in differentiation. These data indicate that progenitor cells and myelin proteins may be affected in vivo by a decrease in BDNF. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0894-1491
eISSN: 1098-1136
DOI: 10.1002/glia.20969
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2851835
Format
–
Schlagworte
Animals
,
Antigens - metabolism
,
Basal Nucleus of Meynert - embryology
,
Basal Nucleus of Meynert - growth & development
,
Basal Nucleus of Meynert - metabolism
,
Biomarkers - metabolism
,
Brain-Derived Neurotrophic Factor - genetics
,
Cell Differentiation - genetics
,
Cell Lineage - genetics
,
Down-Regulation - physiology
,
glia
,
glial development
,
growth factors
,
Immunohistochemistry
,
Intracellular Signaling Peptides and Proteins - metabolism
,
MBP
,
Mice
,
Mice, Knockout
,
Mice, Transgenic
,
Myelin Proteins - metabolism
,
neurotrophins
,
NG2
,
Oligodendroglia - cytology
,
Oligodendroglia - metabolism
,
Proteoglycans - metabolism
,
Receptor, trkB - metabolism
,
Stem Cells - cytology
,
Stem Cells - metabolism
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