Details

Autor(en) / Beteiligte

• Pfeufer, Arne
• Heckbert, Susan R
• van Noord, Charlotte
• Marciante, Kristin D
• Arking, Dan E
• Larson, Martin G
• Smith, Albert Vernon
• Tarasov, Kirill V
• Müller, Martina
• Sotoodehnia, Nona
• Sinner, Moritz F
• Verwoert, Germaine C
• Li, Man
• Kao, W H Linda
• Köttgen, Anna
• Coresh, Josef
• Bis, Joshua C
• Psaty, Bruce M
• Rice, Kenneth
• Rotter, Jerome I
• Rivadeneira, Fernando
• Hofman, Albert
• Kors, Jan A
• Stricker, Bruno H C
• Uitterlinden, André G
• van Duijn, Cornelia M
• Beckmann, Britt M
• Sauter, Wiebke
• Gieger, Christian
• Lubitz, Steven A
• Newton-Cheh, Christopher
• Wang, Thomas J
• Magnani, Jared W
• Schnabel, Renate B
• Chung, Mina K
• Barnard, John
• Smith, Jonathan D
• Van Wagoner, David R
• Vasan, Ramachandran S
• Aspelund, Thor
• Eiriksdottir, Gudny
• Harris, Tamara B
• Launer, Lenore J
• Najjar, Samer S
• Lakatta, Edward
• Schlessinger, David
• Uda, Manuela
• Abecasis, Gonçalo R
• Müller-Myhsok, Bertram
• Ehret, Georg B
• Boerwinkle, Eric
• Chakravarti, Aravinda
• Soliman, Elsayed Z
• Lunetta, Kathryn L
• Perz, Siegfried
• Wichmann, H-Erich
• Meitinger, Thomas
• Levy, Daniel
• Gudnason, Vilmundur
• Ellinor, Patrick T
• Sanna, Serena
• Kääb, Stefan
• Witteman, Jacqueline C M
• Alonso, Alvaro
• Benjamin, Emelia J

Titel

Genome-wide association study of PR interval

Ist Teil von

• Nature genetics, 2010-02, Vol.42 (2), p.153-159

Ort / Verlag

New York, NY: Nature Publishing Group

Erscheinungsjahr

2010

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 × 10−8. At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.