UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 23 von 51
Datensatz exportieren als...
BibTeX
Externalizing disorders in American Indians: Comorbidity and a genome wide linkage analysis
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2008-09, Vol.147B (6), p.690-698
Ehlers, Cindy L.
Gilder, David A.
Slutske, Wendy S.
Lind, Penelope A.
Wilhelmsen, Kirk C.
2008
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ehlers, Cindy L.
Gilder, David A.
Slutske, Wendy S.
Lind, Penelope A.
Wilhelmsen, Kirk C.
Titel
Externalizing disorders in American Indians: Comorbidity and a genome wide linkage analysis
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2008-09, Vol.147B (6), p.690-698
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Alcohol dependence is one of the leading causes of morbidity and mortality in Native Americans. Externalizing disorders such as conduct disorder (CD) and antisocial personality disorder (ASPD) have been demonstrated to have significant comorbidity with alcohol dependence in the general population. This study's aims were to: assess the comorbidity of DSM‐III‐R ASPD and CD with alcohol dependence, to map susceptibility loci for ASPD and CD, and to see if there is overlap with loci previously mapped for alcohol dependence phenotypes in 587 American Indians. Alcohol dependence was found to be comorbid with DSM‐III‐R ASPD but not CD. However, the amount of alcohol dependence in the population attributable to ASPD and/or CD is low. ASPD and the combined phenotype of participants with ASPD or CD were both found to have significant heritability, whereas no significant evidence was found for CD alone. Genotypes were determined for a panel of 791 micro‐satellite polymorphisms in 251 of the participants. Analyses of multipoint variance component LOD scores, for ASPD and ASPD/CD, revealed six locations that had a LOD score of 2.0 or above: on chromosome 13 for ASPD and on chromosomes 1, 3, 4, 14, 17, and 20 for ASPD/CD. These results corroborate the importance of several chromosomal regions highlighted in prior segregation studies for externalizing diagnoses. These results also further identify new regions of the genome, that do not overlap with alcohol dependence phenotypes previously identified in this population, that may be unique to either the phenotypes evaluated or this population of American Indians. © 2008 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.30666
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2839892
Format
–
Schlagworte
Acting Out
,
Adolescent
,
Adult
,
Adult and adolescent clinical studies
,
Aged
,
alcohol dependence
,
antisocial personality disorder
,
Biological and medical sciences
,
Chromosome Mapping
,
Classical genetics, quantitative genetics, hybrids
,
Comorbidity
,
conduct disorder
,
Family Health
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Gene Frequency
,
Genetic Linkage
,
Genetics of eukaryotes. Biological and molecular evolution
,
genome scan
,
Genome, Human
,
heritability
,
Human
,
Humans
,
Indians, North American - genetics
,
Indians, North American - psychology
,
Indians, North American - statistics & numerical data
,
Male
,
Medical genetics
,
Medical sciences
,
Mental Disorders - epidemiology
,
Mental Disorders - genetics
,
Middle Aged
,
Native American
,
Personality disorders
,
Prevalence
,
Psychology. Psychoanalysis. Psychiatry
,
Psychopathology. Psychiatry
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX