Details

Autor(en) / Beteiligte

• Wilson, Rachel I
• Bhandawat, Vikas
• Olsen, Shawn R
• Gouwens, Nathan W
• Schlief, Michelle L

Titel

Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations

Ist Teil von

• Nature neuroscience, 2007-11, Vol.10 (11), p.1474-1482

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2007

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• Here we describe several fundamental principles of olfactory processing in the Drosophila melanogaster antennal lobe (the analog of the vertebrate olfactory bulb), through the systematic analysis of input and output spike trains of seven identified glomeruli. Repeated presentations of the same odor elicit more reproducible responses in second-order projection neurons (PNs) than in their presynaptic olfactory receptor neurons (ORNs). PN responses rise and accommodate rapidly, emphasizing odor onset. Furthermore, weak ORN inputs are amplified in the PN layer but strong inputs are not. This nonlinear transformation broadens PN tuning and produces more uniform distances between odor representations in PN coding space. In addition, portions of the odor response profile of a PN are not systematically related to their direct ORN inputs, which probably indicates the presence of lateral connections between glomeruli. Finally, we show that a linear discriminator classifies odors more accurately using PN spike trains than using an equivalent number of ORN spike trains.