Nature neuroscience, 2010-03, Vol.13 (3), p.284-286
- Ding, Xinxin
- Hough, Lindsay B
- Conroy, Jennie L
- Fang, Cheng
- Gu, Jun
- Zeitlin, Scott O
- Yang, Weizhu
- Yang, Jun
- VanAlstine, Melissa A
- Nalwalk, Julia W
- Albrecht, Phillip J
- Mazurkiewicz, Joseph E
- Snyder-Keller, Abigail
- Shan, Zhixing
- Zhang, Shao-Zhong
- Wentland, Mark P
- Behr, Melissa
- Knapp, Brian I
- Bidlack, Jean M
- Zuiderveld, Obbe P
- Leurs, Rob
2010
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- Autor(en) / Beteiligte
- Ding, Xinxin
- Hough, Lindsay B
- Conroy, Jennie L
- Fang, Cheng
- Gu, Jun
- Zeitlin, Scott O
- Yang, Weizhu
- Yang, Jun
- VanAlstine, Melissa A
- Nalwalk, Julia W
- Albrecht, Phillip J
- Mazurkiewicz, Joseph E
- Snyder-Keller, Abigail
- Shan, Zhixing
- Zhang, Shao-Zhong
- Wentland, Mark P
- Behr, Melissa
- Knapp, Brian I
- Bidlack, Jean M
- Zuiderveld, Obbe P
- Leurs, Rob
- Titel
- Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling
- Ist Teil von
- Nature neuroscience, 2010-03, Vol.13 (3), p.284-286
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To assess the importance of brain cytochrome P450 (P450) activity in μ opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated morphine antinociception compared with controls. Pharmacological inhibition of brain P450 arachidonate epoxygenases also blocked morphine antinociception in mice and rats. Our findings indicate that a neuronal P450 epoxygenase mediates the pain-relieving properties of morphine.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-6256eISSN: 1546-1726DOI: 10.1038/nn.2497Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2828325
- Format
- –
- Schlagworte
- Analgesics, Analgesics, Opioid - administration & dosage, Analgesics, Opioid - pharmacology, Animals, Antibodies, Brain, Brain - drug effects, Brain - enzymology, Brain - metabolism, Cytochrome, Cytochrome P-450, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System - drug effects, Cytochrome P-450 Enzyme System - genetics, Cytochrome P-450 Enzyme System - metabolism, Dose-Response Relationship, Drug, Drug dosages, Enzyme Inhibitors - pharmacology, Female, GABA, Genotype & phenotype, Male, Measurement, Mice, Mice, Transgenic, Morphine, Morphine - administration & dosage, Morphine - pharmacology, Narcotics, Neural Pathways - drug effects, Neural Pathways - enzymology, Neural Pathways - metabolism, Neurons - drug effects, Neurons - enzymology, Neurons - metabolism, Neurosciences, Pain - drug therapy, Pain - enzymology, Pain - metabolism, Physiological aspects, Rats, Rats, Sprague-Dawley, Receptors, Opioid, mu - metabolism, Signal Transduction, Time Factors