Details

Autor(en) / Beteiligte

• Fu, Z
• Tindall, D J

Titel

FOXOs, cancer and regulation of apoptosis

Ist Teil von

• Oncogene, 2008-04, Vol.27 (16), p.2312-2319

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein-protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-X(L), respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer.