Current Opinion in Cell Biology, 2002-04, Vol.14 (2), p.196-202
2002
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- Autor(en) / Beteiligte
- Titel
- Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass
- Ist Teil von
- Current Opinion in Cell Biology, 2002-04, Vol.14 (2), p.196-202
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2002
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Phosphatidylinositol 3-kinase lipid products and the Rho GTPases play a central role in transmitting information from chemotactic receptors to the effectors of cell polarity, and recent advances in the field have allowed us to understand these roles more clearly. Emergent properties of positive and negative regulation of these molecules may account for the establishment of cell polarity during chemotaxis for a wide range of cells from Dictyostelium to fibroblasts to neutrophils. Many proteins are necessary for chemotaxis, but how these components interact spatially and temporally to produce cell polarity is not understood. This paper outlines possible regulatory loops that may orchestrate eukaryotic cell polarity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0955-0674eISSN: 1879-0410DOI: 10.1016/S0955-0674(02)00310-1Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2819118
- Format
- –
- Schlagworte
- Animals, Cell Polarity - physiology, chemotaxis, Chemotaxis - physiology, cytoskeletal re-arrangement, eukaryote, feedback regulation, gradient, Humans, lipid, Lysophospholipids, phosphatidylinositol 3-kinase, Phosphatidylinositol 3-Kinases - metabolism, platelet-derived growth factor, Platelet-Derived Growth Factor - metabolism, rho GTP-Binding Proteins - metabolism, Rho GTPase, Signal Transduction - physiology, Sphingosine - analogs & derivatives, Sphingosine - metabolism