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IN VITRO ANTIOXIDANT ACTIVITIES OF THE FRACTIONS OF COCCINIA GRANDIS L. LEAF EXTRACT
Ist Teil von
African journal of traditional, complementary, and alternative medicines, 2007-10, Vol.5 (1), p.61-73
Ort / Verlag
Nigeria: African Ethnomedicines Network
Erscheinungsjahr
2007
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
The present study was aimed at investigating the antioxidant activities
of the various fractions of the hydromethanolic extract of the leaves
of Coccinia grandis L. Voigt. (Cucurbitaceae). The antioxidant
activities of the fractions have been evaluated by using nine in vitro
assays and were compared to standard antioxidants such as ascorbic
acid, α-tocopherol, curcumin and butylated hydroxyl toluene (BHT).
All the fractions showed effective Hdonor activity, reducing power,
free radical scavenging activity, metal chelating ability and
inhibition of β-carotene bleaching. None of the fractions exerted
an obvious pro-oxidant activity. The antioxidant property depends upon
concentration and increased with increasing amount of the fractions.
The free radical scavenging and antioxidant activities may be
attributed to the presence of phenolic and flavonoid compounds present
in the fractions. The results obtained in the present study indicate
that the leaves of C. grandis are a potential source of natural
antioxidant.