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Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma
Cancer, 2009-10, Vol.115 (19), p.4576-4585
Xu, Michelle Z.
Yao, Tzy‐Jyun
Lee, Nikki P. Y.
Ng, Irene O. L.
Chan, Yuk‐Tat
Zender, Lars
Lowe, Scott W.
Poon, Ronnie T. P.
Luk, John M.
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Xu, Michelle Z.
Yao, Tzy‐Jyun
Lee, Nikki P. Y.
Ng, Irene O. L.
Chan, Yuk‐Tat
Zender, Lars
Lowe, Scott W.
Poon, Ronnie T. P.
Luk, John M.
Titel
Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma
Ist Teil von
Cancer, 2009-10, Vol.115 (19), p.4576-4585
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
BACKGROUND: Yes‐associated protein (YAP), a downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse hepatocellular carcinoma (HCC) model. The objective of the current study was to investigate the clinical significance of YAP in HCC and its prognostic values in predicting survival and tumor recurrence. METHODS: The authors collected 177 pairs of tumor and adjacent nontumor tissue from HCC patients with definitive clinicopathologic and follow‐up data. YAP expression was determined by immunohistochemistry, Western blot analysis, and quantitative polymerase chain reaction. Association of YAP with each clinicopathologic feature was analyzed by Pearson chi‐square test, and HCC‐specific disease‐free survival and overall survival by Kaplan‐Meier curves and log‐rank test. Multivariate Cox regression analyses of YAP in HCC were also performed. RESULTS: YAP was expressed in the majority of HCC cases (approximately 62%) and mainly accumulated in the tumor nucleus. Overexpression of YAP in HCC was significantly associated with poorer tumor differentiation (Edmonson grade; P = .021) and high serum α‐fetoprotein (AFP) level (P < .001). Kaplan‐Meier and Cox regression data indicated that YAP was an independent predictor for HCC‐specific disease‐free survival (hazards ratio [HR], 1.653; 95% confidence interval [95% CI], 1.081‐2.528 [P = .02]) and overall survival (HR, 2.148; 95% CI, 1.255‐3.677 [P = .005]). CONCLUSIONS: YAP is an independent prognostic marker for overall survival and disease‐free survival times of HCC patients and clinicopathologically associated with tumor differentiation and serum AFP level. It is a potential therapeutic target for this aggressive malignancy. Cancer 2009. © 2009 American Cancer Society. Yes‐associated protein (YAP) is overexpressed in hepatocellular carcinoma, with poor prognostic outcomes, and is clinically correlated with poor tumor differentiation grade and high serum α‐fetoprotein level. The authors found that YAP is highly associated with aggressive liver cancer, is a new biomarker for this disease, and is a potential therapeutic target.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.24495
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2811690
Format
–
Schlagworte
Biological and medical sciences
,
Biomarkers, Tumor - analysis
,
Carcinoma, Hepatocellular - diagnosis
,
Carcinoma, Hepatocellular - mortality
,
Female
,
Gastroenterology. Liver. Pancreas. Abdomen
,
hepatocellular carcinoma
,
hippo signaling
,
Humans
,
Liver Neoplasms - diagnosis
,
Liver Neoplasms - mortality
,
Liver. Biliary tract. Portal circulation. Exocrine pancreas
,
Male
,
Medical sciences
,
Middle Aged
,
Nuclear Proteins - analysis
,
Prognosis
,
prognostic marker
,
Survival Analysis
,
Transcription Factors - analysis
,
tumor recurrence
,
Tumors
,
Yes‐associated protein
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